When regarding LoRa sensors they work in exactly the same way as Z-wave dittos.
Actuators in different in LoRa. LoRa actuators all expect data in a device-specific format. It is not standardized in the same way as in Z-wave.
When controlling a LoRa device you send a payload to a specific port. In IoT Open this is done by publishing on topic_write on the payload-function that every LoRa-device have.
In the in the IoT Open payload the LoRa payload should be in msgand the port in value.
There is much to read on this topic. In LoRa wan messages from sensors to the server is called uplink and messages from the server to a LoRa device is called downlink.
If you search for LoRa downlink you will probably find a lot to read.
Generally speaking I think LoRa is best suited for uplink traffic even though downlink also works if you don't expect too fast response times.